Name: Andressa dos Santos Corrêa
Type: MSc dissertation
Publication date: 30/06/2017
Advisor:

Namesort descending Role
Marco Cesar Cunegundes Guimarães Advisor *

Examining board:

Namesort descending Role
André Romero da Silva External Examiner *
Breno Valentim Nogueira Internal Examiner *
Daniela Amorim Melgaço Guimarães do Bem Internal Alternate *
Josimar Ribeiro External Alternate *
Marco Cesar Cunegundes Guimarães Advisor *

Summary: The capping of gold nanocrystals using sodium citrate with Virola oleifera was the focus of this thesis, which aim/aiming at synthesize and characterize evaluate the final extract concentration and pH influence in surface particle adsorption. Furthermore, was analysed antioxidant activity and citotoxicity of AuNPs, for investigate your potential biological application. For this goal, the best capping time, and subsequently the optimum pH range and final extract concentration was determined and was realizes a 32 factorial design with 3 levels and 2 variables (pH and extract concentration) to verify the optimal capping conditions. In this way, it has been proved the adsorption was most intense between pH 3 and 5 and the most stable was the lower final extract concentration. The x-ray diffraction and the transmission electron microscopy confirmed the face-centered cubic structure of citrate AuNPs and the quasi spherical aspect, respectively. The adsorption of aromatic molecules was confirmed by spectroscopy techniques: Fourier-Transform Infrared (FTIR) and Raman. The DPPH and FRAP analyzes shows enhancement of antioxidant activity with capping of citrate gold nanoparticles. Furthermore, the citotoxicity assay shows low citotoxicity of capped gold nanoparticles.

Keywords: metallic nanoparticles, antioxidants and immunologic citotoxicity.

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