Sex-dependent effect of Kombucha intake in a depressive/anxious behavior model induced by LPS in mice

Name: Estela Alves BatistaType: MSc dissertationPublication date: 31/01/2022Advisor:

Namesort descending Role
Cristina Martins e Silva Advisor *

Examining board:

Namesort descending Role
Cristina Martins e Silva Advisor *
Juliana Barbosa Coitinho Goncalves Co advisor *
Marco Cesar Cunegundes Guimarães Internal Examiner *
Vanessa Beijamini Harres External Examiner *

Summary: Major Depressive Disorder (MDD) is a highly prevalent psychiatric disorder of multifactorial origin, and the immune system may be involved in the changes that lead to this pathology. Antidepressant drugs represent the principal form of treatment for MDD; however, their efficacy is limited, around 1/3 of patients respond to treatment with these drugs, which makes necessary to develop new therapeutic approaches for this disorder. The preclinical model of induction of inflammatory cytokines through lipopolysaccharide (LPS) shows the role of neuroinflammation in triggering depressive- like behaviors. Kombucha (KT), a fermented beverage made with Camelia Sinensis, has been considered a good candidate for enhancing mental health through immune regulation. Thus, this study aimed to evaluate the neuromodulatory potential of KT on LPS-induced depressive/anxious-like behavior. For this, male and female mice were treated with kombucha (at a dose of 2mg/kg for 10 days) and subjected to a depressive-like behavior model by LPS (0.83mg/kg i.p). After 24 hours of LPS administration, the animals were submitted to behavioral tests: open field, light dark box, and tail suspension test. The results obtained demonstrate that KT has the potential to reverse depressive-like behavior and attenuate anxious-like behavior and hypolocomotion caused by LPS in females. However, in males, the effect of the consumption of this beverage on anxious behavior and the open field test was not observed, still, LPS did not cause an increase in immobility in the tail suspension test. Therefore, it is suggested that the consumption of KT has beneficial effects on the modulation of depressive/anxious behavior in females and they are more sensitive to LPS-induced behavioral changes.

Keywords: Major Depressive Disorder (MDD), kombucha, lipopolysaccharide; depressive-like behavior.Access to document

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